{"id":10511,"date":"2022-01-23T21:03:40","date_gmt":"2022-01-23T21:03:40","guid":{"rendered":"https:\/\/content.technikum-wien.at\/?post_type=research-projects&p=10453"},"modified":"2025-04-08T07:41:24","modified_gmt":"2025-04-08T07:41:24","slug":"spheriograph","status":"publish","type":"research-projects","link":"https:\/\/content.technikum-wien.at\/forschungsprojekte\/spheriograph\/","title":{"rendered":"SPHERIOGRAPH"},"content":{"rendered":"\n
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SPHERIOGRAPH<\/h1>\n<\/div>\n<\/div>\n\n\n\n
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Home<\/a><\/div>\n\n\n\n
Forschung<\/a><\/div>\n\n\n\n
Projekt SPHERIOGRAPH<\/div>\n<\/div>\n\n\n\n
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Das Projekt \u201eDynamic column-based 3D cell culture method for drug and radiotracer evaluation\u201d wird in Kooperation mit der Firma DOC Medikus GmbH und der Medizinischen Universit\u00e4t Wien (Verena Pichler, PhD, klinische Abteilung f\u00fcr Nuklearmedizin) durchgef\u00fchrt. Dieses Projekt soll durch die Kombination von Erfahrungen aus dem Tissue Engineering bzw. der 3D Zellkultivierung mithilfe von Biomaterialien (FHTW) mit Methoden der Nuklearmedizin (MedUni Wien) zur Entwicklung eines neuen Testsystems f\u00fcr Radiotracer f\u00fchren. Das neuentwickelte System soll zu einer effizienteren PET-Tracerentwicklung (PET… Positronen-Emissions-Tomographie) und damit genaueren Detektierung und angepassten Therapie von Krebsgewebe beitragen. Weiters hat Spheriograph das Potential die ben\u00f6tigten Tierversuche im Rahmen einer Medikamentenentwicklung deutlich zu reduzieren.<\/p>\n<\/div>\n\n\n\n

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<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":9,"template":"","research-topics":[101],"funding-sources":[658],"ppma_author":[2419],"class_list":["post-10511","research-projects","type-research-projects","status-publish","hentry","research-topics-tissue-engineering-molecular-life-science-technologies","funding-sources-ffg"],"acf":{"startDate":"April 1, 2020","endDate":"March 31, 2024","contact":[{"ID":5810,"post_author":"15","post_date":"2021-11-23 00:32:05","post_date_gmt":"2021-11-23 00:32:05","post_content":"\n
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Expertise<\/a><\/div>\n\n\n\n
publications<\/a><\/div>\n\n\n\n
projects<\/a><\/div>\n\n\n\n
CV<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n
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publications (ORCID)<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
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Expertise<\/h2>\n<\/div>\n\n\n\n
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Keywords:<\/strong> Biomaterials \u00b7 Regenerative Medicine \u00b7 Tissue Engineering \u00b7 Structural Protein Biomaterials \u00b7 Silk Fibroin \u00b7 Collagen \u00b7 Fibrin \u00b7 Biomedical Engineering \u00b7 Biomaterial Design \u00b7 Fiber-Based Biomaterials \u00b7 Regenerative Implants \u00b7 ACL Repair \u00b7 Nerve Regeneration \u00b7 Tendon Engineering \u00b7 Muscle Engineering \u00b7 Nerve Guidance Conduits \u00b7 Bioreactors \u00b7 Mechanobiology \u00b7 Shockwave Therapy \u00b7 Cell Activation \u00b7 Translational Research \u00b7 Interdisciplinary Research<\/em><\/p>\n<\/div>\n\n\n\n

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Andreas Teuschl-Woller is a Professor at UAS Technikum Wien and Head of the research focus \u201cBioengineering & Molecular Life Science Technologies\u201d (https:\/\/www.technikum-wien.at\/forschungsschwerpunkt-tissue-engineering-molecular-life-science-technologies\/). He leads interdisciplinary research integrating engineering, biology, and materials science, with a focus on biomaterial development and tendon, muscle, and nerve tissue engineering.<\/p>\n\n\n\n

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His work centers on the use of structural proteins\u2014particularly silk fibroin, as well as collagen and fibrin\u2014as functional materials in biomedical applications. He received his Venia docendi in 2020 in \u201cStructural Proteins as Materials in Biomedical Engineering\u201d from TU Wien and was a guest researcher at Tufts University (Boston) in 2016 in the lab of David Kaplan.<\/p>\n\n\n\n

He has developed innovative silk-processing technologies, including methods for sericin removal and controlled fiber architecture, enabling the translation of silk into clinically relevant regenerative solutions. He also contributed to understanding molecular mechanisms of regeneration, including shockwave-induced cell activation.<\/p>\n\n\n\n

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As coordinator of the City of Vienna project reacTIssue (2012), he initiated bioreactor development at UAS Technikum Wien, forming the basis for subsequent programs such as signalTissue. He has authored more than 50 publications in the fields of biomaterials and tissue engineering.<\/p>\n\n\n\n

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He is co-founder and Chief Scientific Officer of MorphoMed GmbH, where he advances regenerative implants, including biodegradable solutions for ACL repair and nerve guidance conduits.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Publications, 5 last years (peer-reviewed)<\/h2>\n<\/div>\n\n\n\n
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  1. Schneider C, Zehetner J, Sch\u00e4dl B, Domke M, Keibl C, Rieder B, Heimel P, Kleiner A, Teuschl-Woller A<\/strong>, Wolbank S, Redl H, N\u00fcrnberger S. (2025) Femtosecond Laser Engraving Promotes the Repopulation of Decellularized Human Articular Cartilage. J Tissue Eng Regen Med 2025 Dec 30:2025:2334978. doi: 10.1155\/term\/2334978.<\/li>\n\n\n\n
  2. Duman I, Schwingenschl\u00f6gl-Maisetschl\u00e4ger V, Okuducu C, Kraule C, Sami H, Ogris M, Teuschl-Woller A<\/strong>, Pichler V. Integrated approach to cell growth and recovery in silk fibroin scaffolds via a spin-down system. Biomater Biosyst. 2025 Aug 11:19:100118. doi: 10.1016\/j.bbiosy.2025.100118.<\/li>\n\n\n\n
  3. Szwarc-Hofbauer D, Simb\u00f6ck E, Hromada C, Stoiber M, Tomasch J, Weitzer G, Teuschl-Woller A.<\/strong> Purinergic receptors play a key role in shock wave-induced proliferation. Sci Rep. 2025 May 31;15(1):19138. doi: 10.1038\/s41598-025-02955-3.<\/li>\n\n\n\n
  4. Fritz J, Moser AC, Otahal A, Kramer K, Casurovic S, Teuschl-Woller AH<\/strong>, Nehrer S. Hydrostatic Pressure Enhances Chondrogenic Differentiation of Mesenchymal Stem Cells in Silk Fibroin-Based 3D Bioprinted Hydrogels. Biomacromolecules. 2025 Jun 9;26(6):3432-3445. doi: 10.1021\/acs.biomac.5c00048.<\/li>\n\n\n\n
  5. Schwingenschl\u00f6gl-Maisetschl\u00e4ger V, Vila XM, Duman I, Okuducu C, Kuess P, Hacker M, Kraule C, Teuschl-Woller A<\/strong>, Pichler V. Production of detergent-free PET and biodegradable PBAT micro- and nanoplastics. J Hazard Mater. 2025 Aug 5;493:138371. doi: 10.1016\/j.jhazmat.2025.138371.<\/li>\n\n\n\n
  6. Pichler V, Schwingenschl\u00f6gl-Maisetschl\u00e4ger V, Duman I, Monforte X, Ponti S, Zimmermann L, Joldic E, Dumanic M, Vraka C, Hacker M, Kraule C, Teuschl-Woller AH<\/strong>. Bioanalytic Hybrid System Merging 3-Dimensional Cell Culture and Chromatographic Precision for Unprecedented Preclinical Insights in Molecular Imaging. J Nucl Med. 2025 May 1;66(5):813-816. doi: 10.2967\/jnumed.124.269133.<\/li>\n\n\n\n
  7. Fritz J, Moser AC, Otahal A, Redl H, Teuschl-Woller AH<\/strong>, Schneider KH, Nehrer S. Silk Fibroin-Based Hydrogels Supplemented with Decellularized Extracellular Matrix and Gelatin Facilitate 3D Bioprinting for Meniscus Tissue Engineering. Macromol Biosci. 2025 Jun;25(6):e2400515. doi: 10.1002\/mabi.202400515.<\/li>\n\n\n\n
  8. Hromada C, Heimel P, Kerbl M, G\u00e1l L, N\u00fcrnberger S, Schaedl B, Ferguson J, Swiadek N, Monforte X, Heinzel JC, N\u00f3gr\u00e1di A, Teuschl-Woller AH<\/strong>, Hercher D. Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve. Neural Regen Res. 2025 Jun 1;20(6):1789-1800. doi: 10.4103\/NRR.NRR-D-23-01518.<\/li>\n\n\n\n
  9. \u00c1lvarez S, Morales J, Tiozzo-Lyon P, Berrios P, Barraza V, Simpson K, Ravasio A, Monforte Vila X, Teuschl-Woller A<\/strong>, Schuh CMAP, Aguayo S. (2024) Microfabrication-based engineering of biomimetic dentin-like constructs to simulate dental aging. Lab Chip. Jan 31. doi: 10.1039\/d3lc00761h<\/a><\/li>\n\n\n\n
  10. Hromada C, Szwarc-Hofbauer D, Quyen Nguyen M, Tomasch J, Purtscher M, Hercher D, Teuschl-Woller AH<\/strong>. (2024) Strain-induced bands of B\u00fcngner formation promotes axon growth in 3D tissue-engineered constructs. J Tissue Eng. Jan 18;15:20417314231220396. doi: 10.1177\/20417314231220396<\/a><\/li>\n\n\n\n
  11. Schneider KH, Goldberg BJ, Hasturk O, Mu X, D\u00f6tzlhofer M, Eder G, Theodossiou S, Pichelkastner L, Riess P, Rohringer S, Kiss H, Teuschl-Woller AH<\/strong>, Fitzpatrick V, Enayati M, Podesser BK, Bergmeister H, Kaplan DL. (2023) Silk fibroin, gelatin, and human placenta extracellular matrix-based composite hydrogels for 3D bioprinting and soft tissue engineering. Biomater Res. Nov 17;27(1):117. doi: 10.1186\/s40824-023-00431-5<\/a><\/li>\n\n\n\n
  12. Hanetseder D, Levstek T, Teuschl-Woller AH<\/strong>, Frank JK, Schaedl B, Redl H, Marolt Presen D. (2023) Engineering of extracellular matrix from human iPSC-mesenchymal progenitors to enhance osteogenic capacity of human bone marrow stromal cells independent of their age. Front Bioeng Biotechnol. Aug 2;11:1214019. doi: 10.3389\/fbioe.2023.1214019<\/a><\/li>\n\n\n\n
  13. Tomasch J, Maleiner B, Hromada C, Szwarc-Hofbauer D, Teuschl-Woller AH<\/strong>. (2023) Cyclic Tensile Stress Induces Skeletal Muscle Hypertrophy and Myonuclear Accretion in a 3D Model. Tissue Eng Part A. May;29(9-10):257-268. doi: 10.1089\/ten.TEA.2022.0182<\/a><\/li>\n\n\n\n
  14. Bernhard JC, Marolt Presen D, Li M, Monforte X, Ferguson J, Leinfellner G, Heimel P, Betti SL, Shu S, Teuschl-Woller AH<\/strong>, Tangl S, Redl H, Vunjak-Novakovic G. (2022) Effects of Endochondral and Intramembranous Ossification Pathways on Bone Tissue Formation and Vascularization in Human Tissue-Engineered Grafts. Cells. Sep 29;11(19):3070. doi: 10.3390\/cells11193070<\/a><\/li>\n\n\n\n
  15. Angelova L, Daskalova A, Filipov E, Vila XM, Tomasch J, Avdeev G, Teuschl-Woller AH<\/strong>, Buchvarov I. (2022) Optimizing the Surface Structural and Morphological Properties of Silk Thin Films via Ultra-Short Laser Texturing for Creation of Muscle Cell Matrix Model. Polymers (Basel). Jun 25;14(13):2584. doi: 10.3390\/polym14132584<\/a><\/li>\n\n\n\n
  16. Hromada C, Hartmann J, Oesterreicher J, Stoiber A, Daerr A, Sch\u00e4dl B, Priglinger E, Teuschl-Woller AH, Holnthoner W, Heinzel J, Hercher D. (2022)  Occurrence of Lymphangiogenesis in Peripheral Nerve Autografts Contrasts Schwann Cell-Induced Apoptosis of Lymphatic Endothelial Cells In Vitro. Biomolecules. Jun 12;12(6):820. doi: 10.3390\/biom12060820<\/a><\/li>\n\n\n\n
  17. Tomasch J, Maleiner B, Heher P, Rufin M, Andriotis OG, Thurner PJ, Redl H, Fuchs C, Teuschl-Woller AH<\/strong>. (2022) Changes in Elastic Moduli of Fibrin Hydrogels Within the Myogenic Range Alter Behavior of Murine C2C12 and Human C25 Myoblasts Differently. Front Bioeng Biotechnol. May 20;10:836520.doi: 10.3389\/fbioe.2022.836520<\/a><\/li>\n\n\n\n
  18. Deininger C, Wagner A, Heimel P, Salzer E, Vila XM, Wei\u00dfenbacher N, Grillari J, Redl H, Wichlas F, Freude T, Tempfer H, Teuschl-Woller AH<\/strong>, Traweger A. (2021) Enhanced BMP-2-Mediated Bone Repair Using an Anisotropic Silk Fibroin Scaffold Coated with Bone-like Apatite. Int J Mol Sci. Dec 28;23(1):283. 10.3390\/ijms23010283<\/a><\/li>\n\n\n\n
  19. Hackethal J, Weihs AM, Karner L, Metzger M, Dungel P, Hennerbichler S, Redl H, Teuschl-Woller AH.<\/strong> (2021) Novel Human Placenta-Based Extract for Vascularization Strategies in Tissue Engineering.  Tissue Eng Part C Methods. Nov;27(11):616-632. doi: 10.1089\/ten.TEC.2021.0173<\/a><\/li>\n\n\n\n
  20. Hackethal J, Dungel P, Teuschl AH<\/strong>. (2021) Frequently Used Strategies to Isolate Extracellular Matrix Proteins from Human Placenta and Adipose Tissue. Tissue Eng Part C Methods. Dec;27(12):649-660. doi: 10.1089\/ten.TEC.2021.0150<\/a><\/li>\n\n\n\n
  21. Khimich MA, Prosolov KA, Mishurova T, Evsevleev S, Monforte X, Teuschl AH<\/strong>, Slezak P, Ibragimov EA, Saprykin AA, Kovalevskaya ZG, Dmitriev AI, Bruno G, Sharkeev YP. (2021) Advances in Laser Additive Manufacturing of Ti-Nb Alloys: From Nanostructured Powders to Bulk Objects. Nanomaterials (Basel). Apr 29;11(5):1159. doi: 10.3390\/nano11051159<\/a><\/li>\n\n\n\n
  22. Farokhi M, Aleemardani M, Solouk A, Mirzadeh H, Teuschl AH<\/strong>, Redl H. (2021) Crosslinking strategies for silk fibroin hydrogels: promising biomedical materials. Biomed Mater. Feb 17;16(2):022004. doi: 10.1088\/1748-605X\/abb615<\/a><\/li>\n\n\n\n
  23. Ziadlou R, Rotman S, Teuschl A<\/strong>, Salzer E, Barbero A, Martin I, Alini M, Eglin D, Grad S. (2021) Optimization of hyaluronic acid-tyramine\/silk-fibroin composite hydrogels for cartilage tissue engineering and delivery of anti-inflammatory and anabolic drugs. Mater Sci Eng C Mater Biol Appl. Jan;120:111701. doi: 10.1016\/j.msec.2020.111701<\/a><\/li>\n\n\n\n
  24. N\u00fcrnberger S, Schneider C, Keibl C, Sch\u00e4dl B, Heimel P, Monforte X, Teuschl AH<\/strong>, Nalbach M, Thurner PJ, Grillari J, Redl H, Wolbank S. (2021) Repopulation of decellularised articular cartilage by laser-based matrix engraving. EBioMedicine. Feb;64:103196. doi: 10.1016\/j.ebiom.2020.103196<\/a><\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
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    Projects<\/h2>\n<\/div>\n\n\n\n
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    Title<\/div>\n\n\n\n
    Number<\/div>\n\n\n\n
    Duration<\/div>\n\n\n\n
    Funding<\/div>\n\n\n\n
    Link to description<\/div>\n<\/div>\n\n\n\n
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    PrintTissue\u00a0(Biologischer 3D-Druck in der medizinischen Anwendung und\u00a0Technoligieentwicklung)\u00a0<\/div>\n\n\n\n
    MA23 #40-03\u202f\u00a0<\/div>\n\n\n\n
    2025-2029\u202f<\/div>\n\n\n\n
    Stadt Wien<\/div>\n\n\n\n
    Project<\/a><\/div>\n<\/div>\n\n\n\n
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    Mpdetox\u00a0\u2013 Targeting microplastic detoxification mechanisms for urban soil health\u202f\u00a0<\/div>\n\n\n\n
    WWTF ESR-24012\u202f\u00a0<\/div>\n\n\n\n
    2025-2029<\/div>\n\n\n\n
    WWTF<\/div>\n\n\n\n
    Project<\/div>\n<\/div>\n\n\n\n
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    ArtNerve\u00a0\u2013 Entwicklung k\u00fcnstlicher Nerventransplantate\u202f\u00a0<\/div>\n\n\n\n
    FFG Fellowship Projekt\u202f\u00a0<\/div>\n\n\n\n
    2025-2026\u202f\u00a0<\/div>\n\n\n\n
    FFG<\/div>\n\n\n\n
    Project<\/a><\/div>\n<\/div>\n\n\n\n
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    Sequence\u00a0Tissue \u2013\u00a0DNA Sequenzierung\u00a0als interdisziplin\u00e4re Schnittstelle zwischen\u00a0Molecular\u00a0Life Science und Informatik\u202f\u00a0<\/div>\n\n\n\n
    MA23 #32-06\u202f\u00a0<\/div>\n\n\n\n
    2022-2027\u202f<\/div>\n\n\n\n
    Stadt Wien<\/div>\n\n\n\n
    Project<\/a><\/div>\n<\/div>\n\n\n\n
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    Mature\u00a0Tissue\u00a0Doktoratskolleg\u00a0(FHTW & TU Wien)\u202f\u00a0<\/div>\n\n\n\n
    FWF, DFH 28\u00a0doc.funds.connect\u202f\u00a0<\/div>\n\n\n\n
    2022-2026\u202f<\/div>\n\n\n\n
    FWF<\/div>\n\n\n\n
    Project<\/a><\/div>\n<\/div>\n\n\n\n
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    ImmunTissue\u00a0\u2013\u00a0Makrophagenbasierte\u00a0in vitro Analysenplattform zur biologischen\u00a0Implantattestung\u202f\u00a0<\/div>\n\n\n\n
    MA23 #30-06\u202f\u00a0<\/div>\n\n\n\n
    2022-2025\u202f<\/div>\n\n\n\n
    Stadt Wien<\/div>\n\n\n\n
    Project<\/a><\/div>\n<\/div>\n\n\n\n
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    Histo-Zytometrie\u00a0\u2013 computerunterst\u00fctze Analysen der\u00a0Zytoarchitektur\u00a0und Gewebemorphologie\u202f\u00a0<\/div>\n\n\n\n
    MA23 #30-10\u202f\u00a0<\/div>\n\n\n\n
    2021-2025\u202f<\/div>\n\n\n\n
    Stadt Wien<\/div>\n\n\n\n
    Project<\/a><\/div>\n<\/div>\n\n\n\n
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    Spheriograph\u00a0\u2013 Dynamic column-based 3D cell culture methods for drug and radiotracer evaluation\u202f\u00a0<\/div>\n\n\n\n
    FFG-Bridge-Projekt #877136\u202f\u00a0<\/div>\n\n\n\n
    2020-2023\u202f<\/div>\n\n\n\n
    FFG<\/div>\n\n\n\n
    Project<\/a><\/div>\n<\/div>\n\n\n\n
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    Kompetenzteam f\u00fcr Forschung\u00a0SignalTissue\u202f\u00a0<\/div>\n\n\n\n
    MA23 #18-08\u202f\u00a0<\/div>\n\n\n\n
    2016-2019\u202f\u00a0<\/div>\n\n\n\n
    Stadt Wien<\/div>\n\n\n\n
    Project<\/div>\n<\/div>\n\n\n\n
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    Disease Tissue\u202f\u00a0<\/div>\n\n\n\n
    FFG\/COIN #845443\u202f\u00a0<\/div>\n\n\n\n
    2014-2019\u202f<\/div>\n\n\n\n
    FFG<\/div>\n\n\n\n
    Project<\/div>\n<\/div>\n\n\n\n
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    Kompetenzteam f\u00fcr Forschung\u00a0reacTissue\u00a0\u2013 Tissue Engineering Bioreaktoren\u202f\u00a0<\/div>\n\n\n\n
    MA27 #12-06\u202f\u00a0<\/div>\n\n\n\n
    2012-2015\u202f<\/div>\n\n\n\n
    Stadt Wien<\/div>\n\n\n\n
    Project<\/div>\n<\/div>\n\n\n\n
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    NewTissue\u00a0- Neue Ans\u00e4tze in der Geweberegeneration und Tissue Engineering\u202f\u00a0<\/div>\n\n\n\n
    FFG\u00a0FHplus\u00a0Strukturaufbauprojekt #818412 & MA23 #06-06\u202f\u00a0<\/div>\n\n\n\n
    2009-2013\u202f\u00a0<\/div>\n\n\n\n
    FFG<\/div>\n\n\n\n
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    Scientific Education<\/h2>\n<\/div>\n<\/div>\n\n\n\n
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    • 2008 \u2013 2012  Ph.D. Studies in Technical Chemistry, Technical University of Vienna, Austria<\/li>\n\n\n\n
    • 2004 \u2013 2008  Diplom Studies of Technical Chemistry, Technical University of Vienna, Austri<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n
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      Professional Career<\/h2>\n<\/div>\n<\/div>\n\n\n\n
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      • 2022 \u2013 ongoing  Coordinator FWF-funded doc.funds.connect doctoral program MatureTissue, joint doctoral program between FH Technikum Wien and TU Wien<\/li>\n\n\n\n
      • 2020  Venia docendi in Structural Proteins as Materials in Biomedical Engineering, Technische Universit\u00e4t Wien, Vienna, Austria; Spatial transcriptomic and proteomic analysis, 3D modeling of the human liver<\/li>\n\n\n\n
      • 2019 \u2013 ongoing  Head of R&D, Focus Tissue Engineering and Molecular Life Science Technologies University of Applied Sciences Technikum Wien, Vienna, Austria<\/li>\n\n\n\n
      • 2018 \u2013 ongoing  Program Director, Master Tissue Engineering and Regenerative Medicine University of Applied Sciences Technikum Wien, Vienna, Austria<\/li>\n\n\n\n
      • 2016 \u2013 2018  Head of City of Vienna Competence Team, Tissue Engineering Signaltransduction, Department of Biochemical Engineering, University of Applied Sciences Technikum Wien, Vienna, Austria<\/li>\n\n\n\n
      • 2016   Senior Researcher, PI FFG COIN Disease Tissue (Project-# 4443125)<\/li>\n\n\n\n
      • 2015   Invited Researcher, David Kaplan Lab, Tufts University, Boston, USA<\/li>\n\n\n\n
      • 2012 \u2013 2015   Head of City of Vienna Competence Team, Tissue Engineering Bioreactors, Department of Biochemical Engineering, University of Applied Sciences Technikum Wien, Vienna, Austria<\/li>\n\n\n\n
      • 2007 \u2013 2012  Researcher \/ PhD Student \/ Group Leader, Ludwig Boltzmann Institute for Clinical and Experimental Traumatology, Vienna, Austria<\/li>\n<\/ul>\n<\/div>\n<\/div>\n","post_title":"FH-Prof. Priv.-Doz. Dr. techn. 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